![]() It contains the animal imaging mount with rodent alignment stage (a unique platform with adjusters that stereotactically secures mice within a cassette while mounted to a rotational stage) and a hand-held 840 nm SD-OCT probe (HHP) capable of axial resolutions of 5 micrometers (µm) –. Hand-held spectral domain ophthalmic imaging system (SDOIS) (Bioptigen, Inc., Durham, NC) represents an alternative non-invasive in vivo imaging device. Although SD-OCT provides non-invasive histological – grade sections of the rodent posterior segment, image acquisition is technologically cumbersome as human devices are retrofitted for animal use. ![]() With the advent of in vivo applications such as fundoscopy, confocal scanning laser ophthalmoscopy (cSLO), angiography, electroretinography (ERG), and optical coherence tomography (OCT), limitations associated with ex vivo histological preparations can now be circumvented. Inherent methodological limitations confound tissue integrity and curtail longitudinal evaluations within a single subject. Historically, e x vivo histological sectioning is used to study retinal disease in mouse models. Mouse models have been instrumental for understanding pathophysiology in a variety of retinal diseases –. The rapid, high resolution, non-invasive cross-sectional images produced by SD-OCT is an important tool for diagnosing and monitoring posterior segment pathology longitudinally. It suggests that axial elongation takes place predominantly in the equatorial and pre-equatorial region of the eye.Spectral domain optical coherence tomography (SD-OCT) is an important imaging modality in clinical ophthalmology and vision science for characterizing morphology and understanding pathophysiological changes within the retina. Myopic axial globe elongation was associated with retinal thinning in the equatorial and pre-equatorial region, while foveal retinal thickness was mostly unaffected by axial length. In the histomorphometric part of the study including 32 eyes (sagittal diameter: 27.0 ± 4.2 mm range: 22-37 mm), mean thickness of the inner and outer nuclear layers at the equator and at the midpoint equator/posterior pole decreased with longer axial length (P = 0.004 beta: -0.48 and P = 0.02 beta: -0.44, respectively). In the same multivariate model, superior, inferior, and temporal foveal thickness was not significantly associated with axial length (P = 0.26, P = 0.19, P = 0.08, respectively), while thicker nasal foveal thickness was associated with longer axial length (P = 0.009 beta: 0.09 B: 1.50 95% CI: 0.37, 2.62). The study included 1117 individuals with a mean age of 64.2 ± 9.7 years (range: 50-93 years) and mean axial length of 23.4 ± 1.04 mm (range: 20.29-28.68 mm). ![]() Inner and outer nuclear layer thickness as surrogate for retinal thickness was assessed in the fundus periphery in human globes enucleated due to malignant uveal melanoma or painful glaucoma. Using optical coherence tomography, foveal retinal thickness was measured in participants of the population-based Beijing Eye Study without optic nerve or macula diseases. To examine the relationships between axial length and foveal and peripheral retinal thickness.
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